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Centre for Biomedical Sciences

Centre for Biomedical Sciences

The Centre of Biomedical Sciences (CBMS) is a group of scientists with shared interest in the understanding of molecular mechanisms of disease and the development of treatments for patients.

Areas of expertise include microbiology, infection and immunology, regenerative molecular medicine, genetic therapies and molecular neuroscience. We collaborate widely and internationally with other institutions, charities and biopharma organisations. Our impressive breadth of research supports innovative teaching within the department.

Our world renowned research is having meaningful translational impact on patient’s lives; two impact case studies from our Centre were submitted for REF2021.

Treating Duchenne Muscular Dystrophy

Improving treatment of drug-resistant epilepsy

 

Get Involved

Find out which Biomedical Sciences projects you can study as part of an MSc Biological Sciences by Research

You can also see what PhD projects we have available here.

Academic Staff

Prof. Popplewell

Professor Popplewell's research focuses on the pre-clinical development of gene therapies for neuromuscular diseases, in particular the muscular dystrophies based on gene addition, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene silencing. This involves the engineering and testing of viral (AAV, lentivirus) and non-viral (plasmid, oligonucleotide) gene therapy vectors in pre-clinical models in the areas of Duchenne muscular dystrophy (DMD), facioscapulohumeral dystrophy (FSHD) and oculopharyngeal muscular dystrophy (OPMD).

Click here to view Professor Popplewell's research profile.

Dr Chen

Dr Philip Chen's lab is primarily interested in understanding the molecular determinants of drug action at ionotropic glutamate receptors and have been involved in identifying novel antagonists acting at AMPA receptors (Chang et al. 2016 and Augustin et al. 2018). Furthermore, we are also interested in understanding the roles played by novel intracellular proteins on glutamate receptor function (Salim et al. 2019). Recently we have also examined the process of RNA editing and have developed a number of novel antisense oligonucleotides that can modify RNA editing at various transcriptional targets (Chaytow et al. 2021). Current work is exploring the subsequent effect of these oligonucleotides on cellular and neuronal function.

Click here to view Philip Chen's research profile.

Dr McEvoy

uses the flipped classroom technique to bring problem-solving into his classroom, and publishes his teaching innovations in the pedagogical literature. His disciplinary research interests include antibiotic resistance in bacterial biofilms. Dr McEvoy is currently the Head of Department of Biological Sciences.

Dr Stuart Snowden’s research focuses on using state of the art mass spectrometry approaches to study the interaction between metabolism health and disease. Some of his recent work has focused on developing methods to measure the metabolite composition of individual cells to assess the role of metabolic heterogeneity in disease aetiology.

Click here to view Stuart Snowden's research profile.

Prof Williams

The Williams group works in the area of ‘Pharmacogenetics and drug discovery’.

Many currently used medicines, natural products, and traditional remedies are effective as medicinal treatments but lack a clear insight to targets and molecular mechanisms. This holds back the development of new medicines and limits our insight to the underlying mechanisms of many diseases. We focus on using an innovative and tractable model system to improve our understanding of these compounds, including identifying direct targets and regulated pathways for numerous compounds used in the treatment of a range of diseases including epilepsy, bipolar disorder, Alzheimer’s disease, cancer and infection. With this information, we have been able to develop safer and more potent medicines that we have validated in preclinical models, human tissue and in clinical trials.

Click here to view Professor William's research profile.

Prof Yanez

Professor Rafael Yáñez has a strong interest in research translation, and extensive experience in gene and cell therapy for both common and rare diseases. He is particularly involved in the development of safer methods, using genome editing (watch a videoclip on his genome editing research) and viral vectors modified to avoid integration in the cellular genome. His latest research is of relevance to neurodegenerative and inherited diseases, including ataxia telangiectasia, spinal muscular atrophy, spinal injury, Parkinson disease, immunodeficiencies and Duchenne muscular dystrophy.

Click here to view Professor Yáñez's research profile.

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